| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375347 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.
Graphical abstractA series of novel sulfonyl- and phosphonyl amidine anti-bone resorptive agents were developed. The structure–activity relationships are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Myung Yun Lee, Myung Hee Kim, Jinho Kim, Seok Hwan Kim, Bum Tae Kim, In Howa Jeong, Sukbok Chang, Seong Hwan Kim, Sung-Youn Chang,