| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375365 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK1 antagonists. In particular, two of the compounds reported exhibited a good pharmacokinetic (PK) profile and produced anxiolytic-like effects in the gerbil foot tapping (GFT) in vivo model.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fabio M. Sabbatini, Romano Di Fabio, Cristiana Griffante, Giorgio Pentassuglia, Laura Zonzini, Sergio Melotto, Giuseppe Alvaro, Anna M. Capelli, Lara Pippo, Elisabetta Perdona’, Yves St. Denis, Silvano Costa, Mauro Corsi,