| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375372 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3 K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and suppression of pathway specific biomakers such as phosphorylation of Akt at T308.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Zecheng Chen, Efren Delos Santos, Osvaldo Dos Santos, Matthew Bursavich, Adam M. Gilbert, John W. Ellingboe, Semiramis Ayral-Kaloustian, Gulnaz Khafizova, Natasja Brooijmans, Robert Mallon,