| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375373 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Incorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M1 positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.
Graphical abstractIncorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M1 positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Organic Chemistry
Authors
Scott D. Kuduk, Christina N. Di Marco, Victoria Cofre, Daniel R. Pitts, William J. Ray, Lei Ma, Marion Wittmann, Matthew Seager, Kenneth Koeplinger, Chuck D. Thompson, George D. Hartman, Mark T. Bilodeau,