| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375395 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Spirodiketopiperazine-based CCR5 antagonists, showing improved pharmacokinetic profiles without reduction in antagonist activity, were designed and synthesized. We also demonstrate the anti-HIV activity of a representative compound 12, as measured in a p24 assay.
Graphical abstractSpirodiketopiperazine-based CCR5 antagonists, which showed improved pharmacokinetic (PK) profiles without reduction of the antagonist activity, were identified.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rena Nishizawa, Toshihiko Nishiyama, Katsuya Hisaichi, Keisuke Hirai, Hiromu Habashita, Yoshikazu Takaoka, Hideaki Tada, Kenji Sagawa, Shiro Shibayama, Kenji Maeda, Hiroaki Mitsuya, Hisao Nakai, Daikichi Fukushima, Masaaki Toda,