| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375412 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
Graphical abstractA facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide mechanism-based inhibitors of the flavoenzyme histone demethylase LSD1.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David M. Gooden, Dawn M.Z. Schmidt, Julie A. Pollock, Ami M. Kabadi, Dewey G. McCafferty,