Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375414 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
2-Hydroxyethyl- and (S)-2-hydroxybutylphosphonic acid were prepared, starting in the latter case from (S)-2-aminobutyric acid. They were fed to cultures of Streptomyces fradiae producing fosfomycin. Only the latter (150 μg/mL of medium) was converted to the ethyl analogue of fosfomycin, isolated as 2-amino-1-hydroxybutylphosphonic acid (3%) in admixture with 2-amino-1-hydroxypropylphosphonic acid (97%) derived from fosfomycin.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anna Schweifer, Friedrich Hammerschmidt,