| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375415 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Macrocyclic peptidyl hydroxamates were designed, synthesized, and evaluated as peptide deformylase (PDF) inhibitors. The most potent compound exhibited tight, slow-binding inhibition of Escherichia coli PDF (KI∗=4.4nM) and had potent antibacterial activity against Gram-positive bacterium Bacillus subtilis (MIC = 2–4 μg/mL).
Graphical abstractMacrocyclic peptidyl hydroxamates were designed, synthesized, and evaluated as peptide deformylase (PDF) inhibitors. The most potent compound exhibited tight, slow-binding inhibition of Escherichia coli PDF (KI∗=4.4nM) and had potent antibacterial activity against Gram-positive bacterium Bacillus subtilis (MIC = 2–4 μg/mL).Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Chemistry
Organic Chemistry
Authors
Gang Shen, Jinge Zhu, Anthony M. Simpson, Dehua Pei,