Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375416 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
SB-3CT is a thiirane-containing inhibitor of the gelatinase class of matrix metalloprotease enzymes. In support of the mechanistic study of this inhibition, the conformational analyses of SB-3CT (and of two methyl-substituted derivatives) were undertaken using X-ray crystallography and molecular dynamics simulation.
Graphical abstractSB-3CT is a thiirane-containing inhibitor of the gelatinase class of matrix metalloprotease enzymes. In support of the mechanistic study of this inhibition, the conformational analyses of SB-3CT (and of two methyl-substituted derivatives) were undertaken using X-ray crystallography and molecular dynamics simulation.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mijoon Lee, Dusan Hesek, Qicun Shi, Bruce C. Noll, Jed F. Fisher, Mayland Chang, Shahriar Mobashery,