| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375419 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Though less potent than the parent natural product leinamycin, S-deoxyleinamycin displays activity against human cancer cell lines that is comparable to many clinically used agents. The results reported here suggest that the 1,2-dithiolan-3-one heterocycle found in S-deoxyleinamycin reacts with thiols to generate a persulfide intermediate (RSS−) that could deliver biologically active polysulfides, hydrogen sulfide, and reactive oxygen species (O2-, H2O2, and HO) to the interior of cells.
Graphical abstractThough less potent than the parent natural product leinamycin, S-deoxyleinamycin displays activity against human cancer cell lines that is comparable to many clinically used agents. The 1,2-dithiolan-3-one heterocycle found in S-deoxyleinamycin may react with thiols to generate a persulfide intermediate (RSS−) that delivers biologically active polysulfides, hydrogen sulfide, and reactive oxygen species (O2-, H2O2, and HO) to the interior of cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
