| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375440 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of compounds originally derived from the vascular endothelial growth factor receptor tyrosine kinase inhibitor, SU5416, was synthesized and evaluated. The most potent compound in this series, compound 7, structurally resembles the potent anti-microtubule agent Combretastatin A-4, inhibited tubulin polymerization, and showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in low to subnanomolar range.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pui-Kai Li, Zili Xiao, Zhigen Hu, Bulbul Pandit, Yanjun Sun, Dan L. Sackett, Karl Werbovetz, Andrew Lewis, Jayasekar Johnsamuel,