| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375456 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
N,N′-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yan Shi, Jing Zhang, Philip D. Stein, Mengxiao Shi, Stephen P. O’Connor, Sharon N. Bisaha, Chi Li, Karnail S. Atwal, Gregory S. Bisacchi, Doree Sitkoff, Andrew T. Pudzianowski, Eddie C. Liu, Karen S. Hartl, Steven M. Seiler, Sonia Youssef,