| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375460 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Pyrimido-oxazepine based sub-micromolar inhibitors (2–4) for Aurora and FLT-3 were designed and synthesized. These preliminary results supported the potential use of pyrimido-oxazepines as a versatile template for developing specific kinase inhibitors.
Graphical abstractThe development of pyrimido-oxazepine based inhibitors for Aurora and FLT-3 is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Weitao Pan, Hu Liu, Yong-Jiang Xu, Xin Chen, Ki Hwan Kim, Daniel L. Milligan, John Columbus, Yaron R. Hadari, Paul Kussie, Wai C. Wong, Marc Labelle,