| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375465 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic urea (I) was undertaken by incorporating acyl groups as P1′ ligands. The extensive SAR study has yielded a series of N-acyl azacyclic ureas (II), which are highly potent against both wild-type and multiple PI-resistant viral strains.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chen Zhao, Hing L. Sham, Minghua Sun, Vincent S. Stoll, Kent D. Stewart, Shuqun Lin, Hongmei Mo, Sudthida Vasavanonda, Ayda Saldivar, Chang Park, Edith J. McDonald, Kennan C. Marsh, Larry L. Klein, Dale J. Kempf, Daniel W. Norbeck,