| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375540 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A novel class of α7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis γ-lactam scaffold has been optimized to reveal highly potent and selective α7 nAChR agonists with in vitro activity and selectivity and with good brain penetration in mice.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Albert Enz, Dominik Feuerbach, Mathias U. Frederiksen, Conrad Gentsch, Konstanze Hurth, Werner Müller, Joachim Nozulak, Bernard L. Roy,