Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375546 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Resorcinarene oxazines bearing four TEMPO fragments at the wide rim of the macrocycle were prepared through the aminomethylation of resorcinarene octols with 4-amino-TEMPO and formaldehyde. Tetra-TEMPO resorcinarenes are efficient scavengers of 1,1-diphenyl-2-picrylhydrazyl radicals. The model studies revealed that macrocyclic structure and intramolecular hydrogen bonding make considerable contribution to antiradical activity of these compounds. Tetra-TEMPO resorcinarenes show also superoxide dismutase-like activity and efficiently inhibit ABAP-induced peroxidation of linoleic acid.
Graphical abstractA resorcinarene oxazines bearing four TEMPO fragments at the wide rim exhibit a strong antiradical and antioxidant properties in model systems.Figure optionsDownload full-size imageDownload as PowerPoint slide