Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375555 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The identification and structure–activity-relationships (SARs) of novel 2-amino benzamide glucokinase activators are described. Compounds in this series were developed to be potent GK activators, and their binding mode to the GK protein was determined by crystal structure analysis. In vivo pharmacokinetic and acute in vivo efficacy studies of compound 18 are also described.
Graphical abstractThe discovery and structure-activity-relationships of novel 2-amino benzamide glucokinase activators are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Teruyuki Nishimura, Tomoharu Iino, Morihiro Mitsuya, Makoto Bamba, Hitomi Watanabe, Daisuke Tsukahara, Kenji Kamata, Kaori Sasaki, Sumika Ohyama, Hideka Hosaka, Mayumi Futamura, Yasufumi Nagata, Jun-ichi Eiki,