Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375562 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A variety of new prodrugs of 2′-methyl cytidine based on acyloxy ethylamino phosphoramidates have been synthesized and tested in vitro and in vivo for their biological activity. Compared with the parent drug a 10- to 20-fold increase in formation of nucleotide triphosphate in rat and human hepatocytes could be achieved.
Graphical abstractThe synthesis and SAR of phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of HCV NS5B polymerase is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Monica Donghi, Barbara Attenni, Cristina Gardelli, Annalise Di Marco, Fabrizio Fiore, Claudio Giuliano, Ralph Laufer, Joseph F. Leone, Vincenzo Pucci, Michael Rowley, Frank Narjes,