| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375562 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A variety of new prodrugs of 2′-methyl cytidine based on acyloxy ethylamino phosphoramidates have been synthesized and tested in vitro and in vivo for their biological activity. Compared with the parent drug a 10- to 20-fold increase in formation of nucleotide triphosphate in rat and human hepatocytes could be achieved.
Graphical abstractThe synthesis and SAR of phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of HCV NS5B polymerase is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Monica Donghi, Barbara Attenni, Cristina Gardelli, Annalise Di Marco, Fabrizio Fiore, Claudio Giuliano, Ralph Laufer, Joseph F. Leone, Vincenzo Pucci, Michael Rowley, Frank Narjes,