| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375578 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure–activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Minoru Ishikawa, Tomohisa Ninomiya, Hirotomo Akabane, Nobuaki Kushida, Go Tsujiuchi, Makoto Ohyama, Shuichi Gomi, Keiko Shito, Takashi Murata,