| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375580 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Sordarin is a unique natural product antifungal agent that is an inhibitor of elongation factor 2. To improve biological activity, we synthesized various compounds by novel modification of the aglycone, sordaricin. As a result, we have discovered the novel sordarin derivative FR290581. This compound exhibited superior activity and a good pharmacokinetic profile, and also displayed good in vivo activity against Candida albicans.
Graphical abstractWe have discovered the novel sordarin derivative FR290581, which exhibited superior activity, a good pharmacokinetic profile and good in vivo activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tadaatsu Hanadate, Masaki Tomishima, Nobuyuki Shiraishi, Daisuke Tanabe, Hiroshi Morikawa, David Barrett, Satoru Matsumoto, Kazumi Ohtomo, Katsuyuki Maki,