Article ID Journal Published Year Pages File Type
1375582 Bioorganic & Medicinal Chemistry Letters 2009 4 Pages PDF
Abstract

Bionanocapsule (BNC) is a hollow nanoparticle composed of L-protein of the hepatitis B virus surface antigen. BNC can deliver genes or drugs into specific human hepatocytes, but delivery is limited to hepatocytes. In this study, we attempted to alter the specificity of BNCs by genetically introducing cell-penetrating peptides (CPPs), such as arginine-rich peptides, into BNCs. The CPP-fused BNC was efficiently internalized into various cell lines in a short period without significant cytotoxicity. These results show that CPP-BNC could be applied as an efficient carrier for gene and drug delivery.

Graphical abstractBionanocapsules displaying cell-penetrating peptide (CPP-BNC) was constructed. CPP-BNC was efficiently internalized into various cell lines in a short time, compared with original BNC.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , ,