Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375586 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Employing an iterative analogue library approach, novel potent and selective glycine transporter 1 (GlyT1) inhibitors containing a 4-pyridin-2-ylpiperidine sulfonamide have been discovered. These inhibitors are devoid of time-dependent CYP inhibition activity and exhibit improved aqueous solubility versus the corresponding 4-phenylpiperidine analogues.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhijian Zhao, William H. Leister, Julie A. O’Brien, Wei Lemaire, David L. Williams Jr., Marlene A. Jacobson, Cyrille Sur, Gene G. Kinney, Doug J. Pettibone, Philip R. Tiller, Sheri Smith, George D. Hartman, Craig W. Lindsley, Scott E. Wolkenberg,