Article ID Journal Published Year Pages File Type
1375586 Bioorganic & Medicinal Chemistry Letters 2009 4 Pages PDF
Abstract

Employing an iterative analogue library approach, novel potent and selective glycine transporter 1 (GlyT1) inhibitors containing a 4-pyridin-2-ylpiperidine sulfonamide have been discovered. These inhibitors are devoid of time-dependent CYP inhibition activity and exhibit improved aqueous solubility versus the corresponding 4-phenylpiperidine analogues.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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