1-Amido-1-phenyl-3-piperidinylbutanes – CCR5 antagonists for the treatment of HIV: Part 2

Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.

Graphical abstractOptimisation of a series of compound 4-piperidinyltriazoles led to the identification of 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.Figure optionsDownload full-size imageDownload as PowerPoint slide