| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375631 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The optimization of compounds from the 3-amido-4-anilinoquinolines series of CSF-1R kinase inhibitors is described. The series has excellent activity and kinase selectivity. Excellent physical properties and rodent PK profiles were achieved through the introduction of cyclic amines at the quinoline 6-position. Compounds with good activity in a mouse PD model measuring inhibition of pCSF-1R were identified.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David A. Scott, Kirsten J. Bell, Cheryl T. Campbell, Donald J. Cook, Les A. Dakin, David J. Del Valle, Lisa Drew, Thomas W. Gero, Maureen M. Hattersley, Charles A. Omer, Boris Tyurin, Xiaolan Zheng,