| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375667 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of thieno[3,2-b]pyrroloazepinones derivatives related to Hymenialdisine were prepared and tested for CHK1 inhibitory activity. Nanomolar inhibitions were achieved when electron-withdrawing substituents were introduced at position 3 of the thiophene ring.
Graphical abstractThieno[3,2-b]pyrroloazepinones analogues of Hymenialdisine were prepared and found to be potent inhibitors of CHK1.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jean-Gilles Parmentier, Bernard Portevin, Roy M. Golsteyn, Alain Pierré, John Hickman, Philippe Gloanec, Guillaume De Nanteuil,