| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375678 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Armin Arabanian, Mahdieh Mohammadnejad, Saeed Balalaie, Jürgen H. Gross,