| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375710 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of pyropheophorbide-a and bacteriopurpurinimides were investigated to understand the correlation between HSA (site II) binding affinity and in vivo photosensitizing activity. In our study, photosensitizers that bound to site II of HSA produced a significant difference in the circular dichroism spectra of the corresponding complexes, especially at Soret band region of the photosensitizers. Our results suggest that CD spectroscopy of the photosensitizer–HSA complexes could be a valuable tool in screening new photosensitizers before evaluating them for in vivo efficacy.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yihui Chen, Razvan Miclea, Thamarapu Srikrishnan, Sathyamangalam Balasubramanian, Thomas J. Dougherty, Ravindra K. Pandey,