| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375714 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Mifepristone is a non-selective antagonist of 3-oxosteroid receptors with both abortifacient and anti-endometriotic activities. Non-steroidal mimetics of mifepristone and progesterone are important templates for modulation of the progesterone receptor (PR). For our PR program, we sought an unexplored, synthetically accessible non-steroidal mimetic of mifepristone, suitable for parallel synthesis of analogues. Docking of compounds into a PR homology model identified 4-substituted pyrazolines, which, when synthesized and tested, exhibited functional antagonism of PR.
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Related Topics
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Chemistry
Organic Chemistry
Authors
David G. Jones, Xi Liang, Eugene L. Stewart, Robert A. Noe, Lara S. Kallander, Kevin P. Madauss, Shawn P. Williams, Scott K. Thompson, David W. Gray, William J. Hoekstra,