Article ID Journal Published Year Pages File Type
1375715 Bioorganic & Medicinal Chemistry Letters 2005 5 Pages PDF
Abstract

Dioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized. Virus production using SIN-IRES-Luc and capsid assembly were monitored to evaluate antiviral activity. A compound with a three-carbon linker chain connecting two dioxane moieties inhibited virus production by 50% at a concentration of 40 μM, while (R)-hydroxymethyldioxane inhibited virus production by 50% at a concentration of 1 μM. Both compounds were not cytotoxic in uninfected BHK cells at concentrations of 1 mM.

Graphical abstractDioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
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