Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375718 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 were manifested with both non-transformed primary neuronal/glial cells and transformed Jurkat cells. The other compounds did not change the viability either of transformed or of non-transformed cells, and induced DNA cleavage to a lesser extent.
Graphical abstractPyrrolobenzodiazepine 8 was synthesized and found to cause cell death in both transformed Jurkat and non-transformed primary neuronal/glial cells, apparently by inducing damage to DNA.Figure optionsDownload full-size imageDownload as PowerPoint slide