| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375727 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A range of natural and unnatural phomactins, recently synthesised in our laboratory, were found to exhibit PAF antagonism with pIC50 values in the range 5.6–6.2. The variation in structural and stereochemical features between the phomactins was found to have only a modest effect on the inhibition of binding of PAF to its human platelet receptors.
Graphical abstractA range of natural and unnatural phomactins, recently synthesised in our laboratory, were found to exhibit PAF antagonism with pIC50 values in the range of 5.6–6.2.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
William P.D. Goldring, Stephen P.H. Alexander, David A. Kendall, Gerald Pattenden,