| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375733 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2–7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure–activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also possessed antibacterial profile against Klebsiella pneumoniae and Escherichia coli whereas 1c showed anticancer activity against Walker 256 Carcinosarcoma in rats.
Graphical abstractA series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2–7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
![Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents](/preview/png/1375733.png "First Page Preview: Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents")