| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375753 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
Graphical abstractA novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James J. Li, Haixia Wang, Jun Li, Fucheng Qu, Stephen G. Swartz, Andrés S. Hernández, Scott A. Biller, Jeffrey A. Robl, Joseph A. Tino, Dorothy Slusarchyk, Ramakrishna Seethala, Paul Sleph, Mujing Yan, Gary Grover, Neil Flynn, Brian J. Murphy,