| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375763 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The esters (2–10) of the ionophore antibiotic Monensin (1) were synthesized by four different methods, which are discussed in detail. These new esters were characterized by various spectroscopic techniques and subsequently tested in the face of their antimicrobial properties. Three derivatives (3, 8 and 10) showed activity against Gram-positive bacteria. Additionally derivative (10) exhibited a relatively low antifungal activity against Candida in contrast to Monensin A.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adam Huczyński, Joanna Stefańska, Piotr Przybylski, Bogumil Brzezinski, Franz Bartl,