Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375770 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12′S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-κB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-κB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cheng-Zhu Wu, Seong Su Hong, Xing Fu Cai, Nguyen Tien Dat, Ji-Xing Nan, Bang Yeon Hwang, Jung Joon Lee, Dongho Lee,