Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375771 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Sargahydroquinoic acid (2), a major active constituent of Sargassum micracanthum collected from the coast of the East Sea in Korea, showed a selective vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with sargahydroquinoic acid may selectively accelerate cerebral blood flow through dilatation of the basilar artery without lowering systemic blood pressure.
Graphical abstractEC50 11.8 μm on basilar artery: 140 μM on Cartoid Artery Selective Index (SI, EC50 for basilar): 11.9.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Byong-Gon Park, Woon-Seob Shin, Yumi Um, Sungsik Cho, Gab-Man Park, Dong-Soo Yeon, Seong-Chun Kwon, Jungyeob Ham, Byoung Wook Choi, Seokjoon Lee,