| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375772 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Three synthetic routes were developed for structure–activity relationship (SAR) studies of HTS-derived isoquinolinone inhibitor probes for the orphan nuclear receptor steroidogenic factor-1 (NR5A1). Among the new analogs reported herein, 31 and 32 have improved potency, lower cellular toxicity, and improved selectivity compared to the initial HTS-derived leads 1 and 2.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joshua Roth, Franck Madoux, Peter Hodder, William R. Roush,