Article ID Journal Published Year Pages File Type
1375778 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract

A small library of 2,2′-[(α,ω-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC50 values lower than that determined for pentamidine against L. donovani.

Graphical abstractThe synthesis and pharmacological profile of novel bisbenzimidazoles is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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