| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375778 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A small library of 2,2′-[(α,ω-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC50 values lower than that determined for pentamidine against L. donovani.
Graphical abstractThe synthesis and pharmacological profile of novel bisbenzimidazoles is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Annie Mayence, Aurélie Pietka, Margaret S. Collins, Melanie T. Cushion, Babu L. Tekwani, Tien L. Huang, Jean Jacques Vanden Eynde,