Article ID Journal Published Year Pages File Type
1375792 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract
Described herein is a set of non-nucleoside, small molecule inhibitors of genotype 1 HCV polymerase based on a benzothiadiazine screening hit. After demonstrating that a methylsulfonylamino D-ring substituent increased the enzyme potency into the low nanomolar range, a minimum core required for activity was explored. We observed that small aromatic rings and alkenyl groups appended to the 5-position of the B-ring were optimal, resulting in inhibitors with low nanomolar potencies.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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