| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375849 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was found.
Graphical abstractTransdermal permeation enhancers based on dicarboxylic acid esters were studied.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michal Novotný, Alexandr Hrabálek, Barbora Janůšová, Jakub Novotný, Kateřina Vávrová,