| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375858 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Most of the 10-substituted triazolylartemisinin synthesized via the Huisgen 1,3-dipolar cylcoaddition of diastereomeric 10-azidoartemisinin (5, 6, and 7) with various alkynes (a–h) exhibit strong growth inhibition activity, even at sub-micromolar concentrations, against various cancer cell lines such as DLD-1, U-87, Hela, SiHa, A172, and B16. In particular, 10b and 10f showed a highly strong cytotoxicity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sungsik Cho, Sangtae Oh, Yumi Um, Ji-Hee Jung, Jungyeob Ham, Woon-Seob Shin, Seokjoon Lee,