Article ID Journal Published Year Pages File Type
1375862 Bioorganic & Medicinal Chemistry Letters 2009 4 Pages PDF
Abstract

A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.

Graphical abstractThe SAR of a series of quinoxaline inhibitors of c-Met kinase is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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