Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375862 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.
Graphical abstractThe SAR of a series of quinoxaline inhibitors of c-Met kinase is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John Porter, Simon Lumb, Fabien Lecomte, James Reuberson, Anne Foley, Mark Calmiano, Kelly le Riche, Helen Edwards, Jean Delgado, Richard J. Franklin, Jose M. Gascon-Simorte, Alison Maloney, Christoph Meier, Mark Batchelor,