| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375863 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of 2-pyridyl pyrimidines, reported inhibitors of Plasmodium falciparum methionine aminopeptidase 1b were synthesized and evaluated for their antiplasmodial activities. An analysis of physicochemical properties demonstrated a link between lipophilicity and antiparasitic activity. Cross screening of the library against cultured Leishmania donovani parasites revealed this class of compounds as potent inhibitors of parasite development in vitro.
Graphical abstractA series of 2-pyridyl pyrimidines has been shown to possess potent in vitro activity against leishmania parasites.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chitalu C. Musonda, Gavin A. Whitlock, Michael J. Witty, Reto Brun, Marcel Kaiser,