| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375865 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure–activity relationships are detailed, along with enzyme and cellular activity.
Graphical abstractNew isoquinoline-based non-nucleoside inhibitors (2, 3) of HCV NS5b RNA-dependent RNA-polymerase are described. Their syntheses and structure–activity relationships are detailed, along with enzyme and cellular activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert T. Hendricks, Stacey R. Spencer, James F. Blake, Jay B. Fell, John P. Fischer, Peter J. Stengel, Vincent J.P. Leveque, Sophie LePogam, Sonal Rajyaguru, Isabel Najera, John A. Josey, Steven Swallow,