| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375874 | Bioorganic & Medicinal Chemistry Letters | 2009 | 8 Pages |
Abstract
5,6-Dihydro-1H-pyridin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Among these, compound 4ad displayed potent inhibitory activities in biochemical and replicon assays (IC50 (1b) < 10 nM; IC50 (1a) < 25 nM, EC50 (1b) = 16 nM), good in vitro DMPK properties, as well as moderate oral bioavailability in monkeys (F = 24%).
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Organic Chemistry
Authors
Frank Ruebsam, Chinh V. Tran, Lian-Sheng Li, Sun Hee Kim, Alan X. Xiang, Yuefen Zhou, Julie K. Blazel, Zhongxiang Sun, Peter S. Dragovich, Jingjing Zhao, Helen M. McGuire, Douglas E. Murphy, Martin T. Tran, Nebojsa Stankovic, David A. Ellis,