| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375877 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The evaluation of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines as inhibitors of the IGF-1R (IGF-IR) receptor tyrosine kinase is reported. Examples demonstrate nanomolar potencies in in vitro enzyme and mechanistic cellular assays as well as promising in vivo pharmacokinetics in rat.
Graphical abstractA series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines are evaluated as IGF-1R inhibitors. Reported examples demonstrate nanomolar potencies in in vitro enzyme and cellular assays as well as promising in vivo pharmacokinetics in rat.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Stanley D. Chamberlain, Joseph W. Wilson, Felix Deanda, Samarjit Patnaik, Anikó M. Redman, Bin Yang, Lisa Shewchuk, Peter Sabbatini, M. Anthony Leesnitzer, Arthur Groy, Charity Atkins, Roseanne Gerding, Anne M. Hassell, Huangshu Lei, Robert A. Mook Jr.,