| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375882 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
We have successfully obtained 1,2,4-oxadiazol-5-one bioisoteres of Am580 or Tazarotene-like retinoids. In particular compound 4 displays an EC50 of 26 nM on RAR-β.
Graphical abstractWe have successfully obtained 1,2,4-oxadiazol-5-one bioisoteres of Am580 or Tazarotene-like retinoids. In particular compound 4 displays an EC50 of 26 nM on RAR-β.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Julie Charton, Rebecca Deprez-Poulain, Nathalie Hennuyer, Anne Tailleux, Bart Staels, Benoit Deprez,