Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375891 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The optimisation of a tertiary sulfonamide high-throughput screening hit is described. A combination of high-throughput chemistry, pharmacophore analysis and in silico PK profiling resulted in the discovery of potent sulfonamide oxytocin receptor antagonists with oral exposure and good selectivity over vasopressin receptors.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nicholas P. Barton, Benjamin R. Bellenie, Andrew T. Doran, Amanda J. Emmons, Jag P. Heer, Cristian M. Salvagno,