Article ID Journal Published Year Pages File Type
1375891 Bioorganic & Medicinal Chemistry Letters 2009 5 Pages PDF
Abstract
The optimisation of a tertiary sulfonamide high-throughput screening hit is described. A combination of high-throughput chemistry, pharmacophore analysis and in silico PK profiling resulted in the discovery of potent sulfonamide oxytocin receptor antagonists with oral exposure and good selectivity over vasopressin receptors.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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