| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375923 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The design, synthesis, and biological activity of biotin-labeled (−)-ternatin are reported. Chemical modification, that is, biotinylation, was conducted using Click chemistry at the 6-position (NMe-d-ProGly moiety), which was a plausible location selected on the basis of our SAR studies. The compound displayed sufficient fat-accumulation inhibitory effect against 3T3-L1 adipocytes for further bio-organic studies.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenichiro Shimokawa, Kaoru Yamada, Osamu Ohno, Yuichi Oba, Daisuke Uemura,