Article ID Journal Published Year Pages File Type
1375926 Bioorganic & Medicinal Chemistry Letters 2009 4 Pages PDF
Abstract

A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G0–G1 phase transition resulting in G0–G1 arrest.

Graphical abstractA series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , ,