Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375926 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G0–G1 phase transition resulting in G0–G1 arrest.
Graphical abstractA series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raed A. Al-Qawasmeh, Yoon Lee, Ming-Yu Cao, Xiaoping Gu, Stéphane Viau, Jeff Lightfoot, Jim A. Wright, Aiping H. Young,